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c5ar antagonist pmx205  (MedChemExpress)


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    MedChemExpress c5ar antagonist pmx205
    A TEM was used to visualize ferroptosis in U87 and U251 cells. Scale bars, 2 μm, and 500 nm. B Protein expression of GPX4 after C5aR1 knockdown, and the related quantitative analysis, ( n = 3, means ± SD, ** P < 0.01, *** P < 0.001). C Protein expression of GPX4 after treatment with different concentrations of <t>PMX205,</t> and the related quantitative analysis, ( n = 3, means ± SD, * P < 0.05). D Abundance of 4-HNE after C5aR1 knockdown, and the related quantitative analysis, ( n = 3, means ± SD, ** P < 0.01). E Intracellular MDA levels after C5aR1 knockdown, and the related quantitative analysis, ( n = 3, means ± SD, * P < 0.05). F GSH level after C5aR1 knockdown, and the related quantitative analysis, ( n = 3, means ± SD, * P < 0.05). G Relative ROS levels after C5aR1 knockdown, and the related quantitative analysis, ( n = 3, means ± SD, * P < 0.05). H Oxidation-induced fluorescence of C11-BODIPY 581/591 in U87/U251 cells transfected with si-C5aR1. Green fluorescence indicates the oxidation reaction (O-BOD), while red fluorescence indicates the reduction reaction (N-BOD) The related quantitative analysis is shown, ( n = 3, means ± SD, ** P < 0.01). Scale bar, 50 μm.
    C5ar Antagonist Pmx205, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 8 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/c5ar antagonist pmx205/product/MedChemExpress
    Average 93 stars, based on 8 article reviews
    c5ar antagonist pmx205 - by Bioz Stars, 2026-02
    93/100 stars

    Images

    1) Product Images from "Intracellular C5aR1 inhibits ferroptosis in glioblastoma through METTL3-dependent m6A methylation of GPX4"

    Article Title: Intracellular C5aR1 inhibits ferroptosis in glioblastoma through METTL3-dependent m6A methylation of GPX4

    Journal: Cell Death & Disease

    doi: 10.1038/s41419-024-06963-5

    A TEM was used to visualize ferroptosis in U87 and U251 cells. Scale bars, 2 μm, and 500 nm. B Protein expression of GPX4 after C5aR1 knockdown, and the related quantitative analysis, ( n = 3, means ± SD, ** P < 0.01, *** P < 0.001). C Protein expression of GPX4 after treatment with different concentrations of PMX205, and the related quantitative analysis, ( n = 3, means ± SD, * P < 0.05). D Abundance of 4-HNE after C5aR1 knockdown, and the related quantitative analysis, ( n = 3, means ± SD, ** P < 0.01). E Intracellular MDA levels after C5aR1 knockdown, and the related quantitative analysis, ( n = 3, means ± SD, * P < 0.05). F GSH level after C5aR1 knockdown, and the related quantitative analysis, ( n = 3, means ± SD, * P < 0.05). G Relative ROS levels after C5aR1 knockdown, and the related quantitative analysis, ( n = 3, means ± SD, * P < 0.05). H Oxidation-induced fluorescence of C11-BODIPY 581/591 in U87/U251 cells transfected with si-C5aR1. Green fluorescence indicates the oxidation reaction (O-BOD), while red fluorescence indicates the reduction reaction (N-BOD) The related quantitative analysis is shown, ( n = 3, means ± SD, ** P < 0.01). Scale bar, 50 μm.
    Figure Legend Snippet: A TEM was used to visualize ferroptosis in U87 and U251 cells. Scale bars, 2 μm, and 500 nm. B Protein expression of GPX4 after C5aR1 knockdown, and the related quantitative analysis, ( n = 3, means ± SD, ** P < 0.01, *** P < 0.001). C Protein expression of GPX4 after treatment with different concentrations of PMX205, and the related quantitative analysis, ( n = 3, means ± SD, * P < 0.05). D Abundance of 4-HNE after C5aR1 knockdown, and the related quantitative analysis, ( n = 3, means ± SD, ** P < 0.01). E Intracellular MDA levels after C5aR1 knockdown, and the related quantitative analysis, ( n = 3, means ± SD, * P < 0.05). F GSH level after C5aR1 knockdown, and the related quantitative analysis, ( n = 3, means ± SD, * P < 0.05). G Relative ROS levels after C5aR1 knockdown, and the related quantitative analysis, ( n = 3, means ± SD, * P < 0.05). H Oxidation-induced fluorescence of C11-BODIPY 581/591 in U87/U251 cells transfected with si-C5aR1. Green fluorescence indicates the oxidation reaction (O-BOD), while red fluorescence indicates the reduction reaction (N-BOD) The related quantitative analysis is shown, ( n = 3, means ± SD, ** P < 0.01). Scale bar, 50 μm.

    Techniques Used: Expressing, Knockdown, Fluorescence, Transfection



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    c5ar antagonist pmx205  (MedChemExpress)
    93
    MedChemExpress c5ar antagonist pmx205
    A TEM was used to visualize ferroptosis in U87 and U251 cells. Scale bars, 2 μm, and 500 nm. B Protein expression of GPX4 after C5aR1 knockdown, and the related quantitative analysis, ( n = 3, means ± SD, ** P < 0.01, *** P < 0.001). C Protein expression of GPX4 after treatment with different concentrations of <t>PMX205,</t> and the related quantitative analysis, ( n = 3, means ± SD, * P < 0.05). D Abundance of 4-HNE after C5aR1 knockdown, and the related quantitative analysis, ( n = 3, means ± SD, ** P < 0.01). E Intracellular MDA levels after C5aR1 knockdown, and the related quantitative analysis, ( n = 3, means ± SD, * P < 0.05). F GSH level after C5aR1 knockdown, and the related quantitative analysis, ( n = 3, means ± SD, * P < 0.05). G Relative ROS levels after C5aR1 knockdown, and the related quantitative analysis, ( n = 3, means ± SD, * P < 0.05). H Oxidation-induced fluorescence of C11-BODIPY 581/591 in U87/U251 cells transfected with si-C5aR1. Green fluorescence indicates the oxidation reaction (O-BOD), while red fluorescence indicates the reduction reaction (N-BOD) The related quantitative analysis is shown, ( n = 3, means ± SD, ** P < 0.01). Scale bar, 50 μm.
    C5ar Antagonist Pmx205, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/c5ar antagonist pmx205/product/MedChemExpress
    Average 93 stars, based on 1 article reviews
    c5ar antagonist pmx205 - by Bioz Stars, 2026-02
    93/100 stars
    		  Buy from Supplier

    Image Search Results


    A TEM was used to visualize ferroptosis in U87 and U251 cells. Scale bars, 2 μm, and 500 nm. B Protein expression of GPX4 after C5aR1 knockdown, and the related quantitative analysis, ( n = 3, means ± SD, ** P < 0.01, *** P < 0.001). C Protein expression of GPX4 after treatment with different concentrations of PMX205, and the related quantitative analysis, ( n = 3, means ± SD, * P < 0.05). D Abundance of 4-HNE after C5aR1 knockdown, and the related quantitative analysis, ( n = 3, means ± SD, ** P < 0.01). E Intracellular MDA levels after C5aR1 knockdown, and the related quantitative analysis, ( n = 3, means ± SD, * P < 0.05). F GSH level after C5aR1 knockdown, and the related quantitative analysis, ( n = 3, means ± SD, * P < 0.05). G Relative ROS levels after C5aR1 knockdown, and the related quantitative analysis, ( n = 3, means ± SD, * P < 0.05). H Oxidation-induced fluorescence of C11-BODIPY 581/591 in U87/U251 cells transfected with si-C5aR1. Green fluorescence indicates the oxidation reaction (O-BOD), while red fluorescence indicates the reduction reaction (N-BOD) The related quantitative analysis is shown, ( n = 3, means ± SD, ** P < 0.01). Scale bar, 50 μm.

    Journal: Cell Death & Disease

    Article Title: Intracellular C5aR1 inhibits ferroptosis in glioblastoma through METTL3-dependent m6A methylation of GPX4

    doi: 10.1038/s41419-024-06963-5

    Figure Lengend Snippet: A TEM was used to visualize ferroptosis in U87 and U251 cells. Scale bars, 2 μm, and 500 nm. B Protein expression of GPX4 after C5aR1 knockdown, and the related quantitative analysis, ( n = 3, means ± SD, ** P < 0.01, *** P < 0.001). C Protein expression of GPX4 after treatment with different concentrations of PMX205, and the related quantitative analysis, ( n = 3, means ± SD, * P < 0.05). D Abundance of 4-HNE after C5aR1 knockdown, and the related quantitative analysis, ( n = 3, means ± SD, ** P < 0.01). E Intracellular MDA levels after C5aR1 knockdown, and the related quantitative analysis, ( n = 3, means ± SD, * P < 0.05). F GSH level after C5aR1 knockdown, and the related quantitative analysis, ( n = 3, means ± SD, * P < 0.05). G Relative ROS levels after C5aR1 knockdown, and the related quantitative analysis, ( n = 3, means ± SD, * P < 0.05). H Oxidation-induced fluorescence of C11-BODIPY 581/591 in U87/U251 cells transfected with si-C5aR1. Green fluorescence indicates the oxidation reaction (O-BOD), while red fluorescence indicates the reduction reaction (N-BOD) The related quantitative analysis is shown, ( n = 3, means ± SD, ** P < 0.01). Scale bar, 50 μm.

    Article Snippet: The apoptosis inhibitor Z-VAD-FMK (HY-16658B, MedChemExpress MCE USA), the ferroptosis inhibitors ferrostatin-1 (HY-100579, MCE, USA) and liproxstatin-1 (HY-12726, MCE, USA), the necroptosis inhibitor necrostatin-1 (HY-15760, MCE, USA), the autophagy inhibitor 3-methyladenine (HY-19312, MCE, USA) and the C5aR antagonist PMX205 (HY-110136A, MCE, USA) were used.

    Techniques: Expressing, Knockdown, Fluorescence, Transfection